Sir William Babthorpe (1489/1490–1555) was an English politician of Osgodby and Flotmanby, Yorkshire.
He held a number of public offices, including membership of the Council of the North from 1536 to his death and the Constableship of Wressle Castle (1513) and was knighted in 1547.
He also served as the Custos Rotulorum of the East Riding of Yorkshire from c. 1547 to his death.
William Babthorpe (died 1581), the eldest succeeded.
Grace was an enthusiastic Roman Catholic and she had her children baptized in that religion, employing an unlicensed Catholic tutor for her children.