William Best (c. 1707 – November 17, 1782) was a political figure in Nova Scotia.
He came to Halifax in 1749 and later settled at Cornwallis.
In 1779, with John Burbidge, he helped establish an Anglican church there.
In 1783, he was named a justice of the peace for King's County.
One of his descendants, Charles Best, discovered insulin with Frederick Banting.