William Campbell Preston (December 27, 1794 – May 22, 1860) was a senator from the United States and a member of the Nullifier, and later Whig Parties.

He then moved to Columbia, South Carolina in 1822 and ran unsuccessfully for election to the Twenty-Second Congress.

He was then elected in 1833 as a Nullifier to the United States Senate to fill the vacancy after the resignation of Stephen D. Miller.

During his first year in the Senate, his oratorical gifts led the Whig leadership to give him a prominent role in the effort to censure Andrew Jackson, elevating Preston "far in advance of most of his colleagues, and side by side with Clay, Webster, Calhoun, and Clayton.

"[3] Preston was then reelected as a Whig in 1837 and served until his resignation on November 29, 1842.