William Carruthers Little (1820 – December 31, 1881) was an Ontario farmer and political figure.

He represented Simcoe South in the House of Commons of Canada as a Liberal-Conservative from 1867 to 1881.

Little was a major in the local militia and also served as president of the Innisfil Agricultural Society.

[3] His son Edward represented Cardwell in the Legislative Assembly of Ontario.

Another son, also named William Carruthers Little, was chief clerk in the Department of Railways and Canals and was also captain of the Ottawa Rough Riders.