Born in Decatur, Illinois, Clothier entered the film industry painting sets at Warner Bros., and at the end of the silent era began photographing such films as Wings (1927) and Ernst Lubitsch's The Patriot (1928).
He advanced to a lieutenant colonel in the United States Air Force during World War II, and flew seventeen missions on the Memphis Belle.
[1] In 1955, Clothier filmed The Sea Chase, his first project as Director of Photography with John Wayne, after which the actor signed him to a contract with his Batjac Productions.
The two went on to collaborate on 21 more films, including John Ford's The Man Who Shot Liberty Valance.
Clothier was nominated for two Academy Awards for Best Cinematography for The Alamo (1960) and Cheyenne Autumn (1964).