He is chiefly remembered as the author of The Three Tours of Doctor Syntax, a comic poem, illustrated by artist Thomas Rowlandson's colour plates, that satirised William Gilpin.
He spent his fortune, travelled and was nicknamed "Count Combe"; and in the period 1769–1773 was low in funds, existing in France, Wales and the West Midlands.
[2] In 1790 and 91, the six volumes of a Devil on Two Sticks in England won for Combe the title of "the English le Sage".
From 1809 to 1811 he wrote for Ackermann's The Poetical Magazine the serialized comic poem The Tour of Dr Syntax in Search of the Picturesque, descriptive and moralizing verse illustrated by artist Thomas Rowlandson's color plates.
[4] Then came Six Poems in illustration of drawings by Princess Elizabeth (1813), The English Dance of Death (1815–1816), The Dance of Life (1816–1817), The Adventures of Johnny Quae Genus (1822)—all written for Rowlandson's caricatures; together with histories of Oxford and Cambridge, and of Westminster Abbey for Ackermann; Picturesque Tours along the Rhine and other rivers, Histories of Madeira, Antiquities of York, texts for Turner's Southern Coast Views, and contributions innumerable to the Literary Repository.