Following high school graduation, DeGrado worked in a coat rack factory, an experience that motivated him to further his education.
Since 2011 he has been at the University of California, San Francisco School of Pharmacy, where he is the Toby Herfindal Presidential Professor of Entrepreneurship and Innovation.
[6] The sequence of alpha3D was designed using the computational sidechain repacking algorithms that had recently been developed by Ponders & Richards,[7][8][9][10] Desjarlais & Handel, Dahiyat & Mayo.
Clinical data announced in 2020 showed deep and durable responses of multiple myeloma, illustrating the potential of de novo proteins for treatment of human disease.
[21] His work on this subject with Dean Sheppard[22] also formed the basis for founding Pliant Pharmaceuticals,[23] a company conducting clinical trials on idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis.