William Frederick DesBarres (1800 – June 1885) was a lawyer, judge and political figure in Nova Scotia, Canada.
He represented Guysborough County in the Nova Scotia House of Assembly from 1836 to 1848 as a Reformer.
He was born in Elysian, Cumberland County, Nova Scotia, the son of John DesBarres.
DesBarres studied law with Lewis Morris Wilkins and Hiram Blanchard, was admitted to the Nova Scotia bar in 1822 and set up practice in Guysborough.
DesBarres built an Egyptian Revival style home in the heart of Guysborough in 1837.