William Henry Harrison Cowles (April 22, 1840 – December 30, 1901) was a North Carolina Democratic politician who served four terms in the United States House of Representatives.
A native of Yadkin County, North Carolina, Cowles served in the Confederate States Army during the American Civil War.
In 1861 he enlisted in the 1st North Carolina Cavalry Regiment and by the war's end had risen to the rank of lieutenant colonel.
He was the uncle of Republican Congressman Charles H. Cowles, and he was the grandfather of Democratic N.C. state Senator Lura S. Tally.
His home and law office at Wilkesboro was listed on the National Register of Historic Places in 1982.