The William Henry Harrison School building, now known as St. Malachy Catholic School, is an historic American structure that is located at 1012 West Thompson Street in the Yorktown neighborhood of Philadelphia, Pennsylvania.

[2] It is a three-story, nine-bay-wide, brick building that sits on a raised basement.

It was designed in the Late Gothic Revival style and features a one-story, stone entrance pavilion with a Tudor-arched opening and a crenellated parapet.

[3] Originally named for President William Henry Harrison, it was renamed as St. Malachy School.

Added to the National Register of Historic Places in 1988,[1] this building is also currently home to the nonprofit Independence Mission Schools, which operates a network of fourteen Catholic schools in the Philadelphia area.