William Henry Brisbane (October 12, 1806 Beaufort County, South Carolina – April 5, 1878 Arena, Wisconsin) was a Baptist minister of the southern United States who, having convinced himself of the immorality of slavery, freed and settled a group of slaves he had inherited, and became an active abolitionist.

[2] He married 28 May 1825 at Lawtonville Glorianna Lawton (15 July 1805 – 17 February 1878), who bore him eight recorded children, of whom three survived to adulthood.

[2] Brisbane inherited a large number of slaves, but became convinced that slavery was wrong, and in 1835 brought 33 of them to the north, manumitting them and aiding them to settle in life.

At this time many family and friends in his social circle, including rice planters, led lives that were economically dependent on slavery.

He published the book, "The Bible defended against the objections of infidelity being an examination of scientific, historical, chronological and other Scripture difficulties."