William Henry Brouse (June 15, 1824 – August 23, 1881) was a Canadian physician and politician.

Born in Matilda Township, Dundas County, Upper Canada of German ancestry, his father was Colonel Jacob Brouse of the Dundas Militia who was one of the first to fire upon the American Army at the Battle of Point Iroquois and commanded the 4th (Winchester) Battalion in the 1850s.

William Brouse attended Upper Canada Academy in Cobourg, Canada West in 1839, Victoria College until 1845, and received his Doctor of Medicine degree in 1847 from McGill College.

He was nominated to the Senate of Canada in 1878 representing the senatorial division of Prescott, Ontario, and sat as a Reformer until his death in 1881.

He was commissioned as the Surgeon of the 56th (Grenville) Battalion of Infantry on April 12, 1867, and was active in matters of the Canadian Militia.