William I. Skinner (October 24, 1812 - February 13, 1891) was an American politician from New York.
He was the son of Josiah Skinner.
He was Sheriff of Herkimer County, New York from 1847 to 1849.
He was a Canal Commissioner from 1860 to 1865, elected in 1859 on the Democratic and American tickets, and re-elected in 1862 on the Democratic ticket.
He was a delegate to the 1864 Democratic National Convention.