Sir William Lygon (1568–1608) was an English politician who sat in the House of Commons at various times between 1589 and 1608.
Lygon was the eldest son of Richard Lygon of Madresfield Court, Worcestershire and his wife Mary Russell, daughter of Sir Thomas Russell of Strensham.
He succeeded to the estates of Madresfield and elsewhere on the death of his father in 1584 but was required to sell off or mortgage much property over the years.
In November 1599 in an improved financial situation, he bought the manor of Pixham, Worcestershire but in 1602 had to sell other property in the manor of Acton Beauchamp.
His son William, who inherited the encumbered estates, had to sell off more of them.