William Calvin Matthews (January 5, 1877 – January 23, 1946) was a right-handed pitcher in Major League Baseball who played briefly for the Boston Red Sox during the 1909 season.

He was born in Mahanoy City, Pennsylvania.

Matthews posted a 3.24 ERA in five appearances, including one start, six strikeout, 10 walks, 16 hits allowed, and 16.2 innings of work.

Matthews died in Mount Carbon, Pennsylvania, at age 68.

This biographical article relating to an American baseball pitcher born in the 1870s is a stub.