His PhD thesis was titled "The Effects of Reversible Denaturation on the Population Distribution of Bovine Serum Albumin" and was submitted in August 1967.
In the late 1960s, Moore joined the faculty of Southern University, his alma mater where he had completed his undergraduate studies.
While at Southern, in 1975, Moore took a yearlong absence to consult 34 historically Black colleges and universities on developing programs in interdisciplinary studies.
In 1981, he served as chairman of the General Research Support Review Committee at the National Institutes of Health.
[8] In 2006, the Purdue Board of Trustees established the William E. Moore Distinguished Professor of Earth and Atmospheric Science and Chemistry and named Joseph S. Francisco as the first to hold this appointment.