William Edward O'Brien (March 11, 1923 – December 1, 2000) was an American football coach and official.
He was the seventh head football coach at the Southern Illinois University Carbondale, serving for three seasons, from 1952 to 1954, and compiling a record of 6–20.
He wore number 83 for the major part of his NFL career.
He died on December 1, 2000, at Cardinal Health Care in Energy, Illinois, after battling Alzheimer's disease for 13 years.
This biographical article relating to a college football coach first appointed in the 1950s is a stub.