Vice-Admiral William O'Brien Drury (1754 – 6 March 1811) was a senior officer of the British Royal Navy during the Napoleonic Wars.

Drury served as commander of the ship of the line HMS Powerful during the French Revolutionary Wars, during which he was heavily engaged at the Battle of Camperdown, at which a Dutch fleet was destroyed in 1797.

[6] Drury was appointed as commander of the East Indies Station in September 1807, after his predecessor Sir Thomas Troubridge had been lost at sea sailing from India to the Cape of Good Hope.

[10] The following month he transferred his flag to HMS Russell and escorted a convoy up the coast to Calcutta (modern Kolkata),[11] returning in June.

The fleet arrived in September 1808 and a detachment of troops were landed, but a lack of support from the Portuguese authorities and strong resistance from the Chinese government meant that the force was withdrawn before it caused a diplomatic crisis between Britain and China.