When the Belfast Hospital for Sick Children was opened in 1878, Reverend O'Neill was appointed as the first president of the Medical Board.
[4] Lord O'Neill married, firstly, Henrietta, daughter of Robert Torrens, judge of the Court of Common Pleas, and his wife Anne, in 1839.
After her death in 1857 he married, secondly, Elizabeth Grace, daughter of the Venerable John Torrens, Archdeacon of Dublin, in 1858; she was Henrietta's first cousin.
His third son from his first marriage, Robert Torrens O'Neill, represented Antrim Mid in Parliament for many years.
He died in April 1883, aged 70, and was succeeded in the barony by his eldest son from his first marriage, Edward.