William Orison Valentine (May 9, 1862– February 2, 1928) was an educator and missionary in service of the American Baptist Foreign Mission Society who established and served as first president of Jaro Industrial School, now Central Philippine University.

Valentine and Miss Van Allen were married in 1903 and the couple left for his new appointment in Iloilo in the Philippines, few years after when the country was opened to Protestant American missions in 1898.

The Republic continues to this day at Central Philippine University which evolved from the Industrial School over the years.

With the completion of his studies in 1916, Valentine received a new appointment as Provincial Missionary for Negros Occidental, an island neighboring Iloilo in the Philippines.

He built a new mission house to replace the small chapel and encouraged Filipino lay ministers to preach at Sunday services.

There were also dormitories for both boys and girls who attended public schools and received a Christian education at the mission.

On February 2, 1928, Valentine died in Bacolod of malaria complicated by heart disease and was buried at the Philippine American Cemetery in Jaro, Iloilo City.