His father, Thomas F. Frist, Jr., is a billionaire who served as the Chairman of the Hospital Corporation of America (HCA).
His paternal uncle, Bill Frist, served as United States Senate Majority Leader from 2003 to 2007.
[9] He serves as the Chairman and President of the Board of Trustees of the Frist Center for the Visual Arts.
[11] He serves as the Second President of the Board of Trust of the Currey Ingram Academy, a private school in Brentwood, Tennessee.
[3] In 2009, he made headlines for purchasing a photograph of the Upper West Side taken in October 1848, before it was built upon, at a Sotheby's auction for US$62,500.