William Shapleigh Damrell (November 29, 1809 – May 17, 1860) was a member of the United States House of Representatives from Massachusetts.

In December 1845, Damrell was the unsuccessful Native American Party (Know Nothing) nominee for mayor of Boston.

Damrell suffered a paralytic stroke before the expiration of his second term, and was not a candidate for renomination in 1858.

His interment was at Forest Hills Cemetery in the Jamaica Plain neighborhood of Boston, Massachusetts.

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