William Samuel Booze (January 9, 1862 – December 6, 1933) was a U.S. Representative from the third district of Maryland.
Afterwards attended the University of Maryland School of Medicine and graduated with a degree in medicine from the College of Physicians and Surgeons, New York City, in 1882.
Booze practiced his profession in Baltimore until 1896, when he was elected to Congress, he previously unsuccessfully contested the election of Harry Welles Rusk to the Fifty-fourth Congress, as a Republican to the Fifty-fifth Congress (March 4, 1897 - March 3, 1899).
He was selected as a delegate to the Republican National Conventions in 1904 and 1908.
Booze died in Wilmington, Delaware, while en route to his home from a trip to South America.