William Spankie (17 October 1859 – 27 May 1934) was a Conservative member of the House of Commons of Canada.
He attended private and public schools in Kingston, Ontario then proceeded to Queen's University where he received Bachelor of Arts, MD and CM degrees.
Spankie served as president of the Medical Councils of Ontario and of Canada.
In 1913, he became a warden of the county, and from that year until 1929 he was reeve of Wolfe Island.
Spankie died on 27 May 1934 before completing his term in the 17th Canadian Parliament.