William Thompson Nuckolls (February 23, 1801 – September 27, 1855) was a U.S. Representative from South Carolina.
Born near Hancockville, Union (now Cherokee) County, South Carolina, Nuckolls graduated from South Carolina College (now the University of South Carolina) at Columbia in 1820.
He was admitted to the bar in 1823 and commenced practice in Spartanburg, South Carolina.
He died on his plantation near Hancockville, South Carolina, on September 27, 1855.
He was interred in Whig Hill Cemetery.