In 1839, he married Emily, daughter of Robert Leslie-Anstruther, and they had two children, Emily Eden (born 21 April 1840, Bhaugulpore,[2] died 27 May 1905[3]) and William Henry (born 1844), before she died in 1844 on return from India.
He then remarried to Harriette, daughter of Ambrose Humphrys, on 2 December 1847,[4] and they had one child, Caroline Bretha (died 1919), before she also died in 1852.
Thirdly, in 1866, he married Melanie, daughter of Sir Richard Jenkins, and they had a son: Charles Edward Bexley (born 1867)[3][5] A liberal-conservative in politics, Vansittart was elected Conservative Party MP for Windsor at the 1857 general election and held the seat until 1865 when he sought re-election as a Liberal Party candidate, but failed.
[6][7] He was also part of the Honourable East India Company and a Deputy Lieutenant.
[3][5] He died in January 1878 from shock after receiving burns to his arm when a lint used to dress a wound to his arm caught fire.