Born near Fishkill, New York, Van Wyck attended the public schools and Fishkill Academy.
Van Wyck was elected as a Democratic-Republican to the 17th and 18th United States Congresses, holding office from December 3, 1821, to March 3, 1825.
He was Chairman of the Committee on Expenditures in the Post Office Department (18th Congress).
He removed to Sudley, Virginia, and engaged in planting.
He returned to Dutchess County, New York, and died in Fishkill.