After his father's death in 1832, he made his debut a week later at the Arch Street Theatre in Philadelphia in the part of Young Norval.

He played a wide variety of characters, from broad and eccentric comedy to juvenile tragedy, with general acceptance.

During the last few years of this period he performed in a company headed by his brother-in-law, John Blake Rice.

His semi-centennial in 1882 brought out many deserved tributes to an admirable comedian and representative of the best traditions of the stage.

Warren was best known for roles such as Dr. Pangloss in The Heir at Law, Sir Peter Teazle in The School for Scandal, Dr. Primrose and Touchstone in As You Like It.