In the 1980s, Winckler appeared as an actor on TV series such as Remington Steele, Knight Rider, Murder, She Wrote, Doogie Howser, M.D., Designing Women, The Fall Guy, and Short Ribbs starring Billy Barty.

[2] In 1984, he produced and directed the English version of the classic Tatsunoko Production Co. Ltd. anime series Tekkaman the Space Knight.

He formed his own production company in 2001, producing and directing as the horror film Frankenstein vs. the Creature from Blood Cove, and the Russ Meyer movie star reunion comedy The Double-D Avenger.

[3][4][5][6][7][8][9][10][2] He produced all-new English movie versions of Toei Animation classics Gaiking, Danguard Ace, Space Pirate Captain Harlock, Fist of the North Star, Ashita no Nadja, Science Fiction Saiyuki Starzinger, Digimon Xros Wars, Yes!

[12][13] From 2015 through 2017, William Winckler wrote, produced and directed the American English language versions of Tsuburaya Productions' Ultra Series feature films.