Worthington was born in 1703 and educated at Oswestry School before moving to Jesus College, Oxford.
He became usher of Oswestry School in 1726 and was ordained priest, becoming vicar of Llanyblodwell in Shropshire in 1729 through Francis Hare, Bishop of St Asaph.
Worthington obtained a Cambridge Master of Arts (MA Cantab) degree from St John's College, Cambridge in 1730, and Bachelor of Divinity (BD) and Doctor of Divinity (DD) degrees from the University of Oxford in 1738.
[2] Worthington wrote on the subject of the Book of Job in An Essay on ... Man's Redemption' (1743), which disagreed with the views of William Warburton (later Bishop of Gloucester).
He wrote on other theological topics, including two replies to a dissenting cleric's Essay on Demoniacks (1777 and 1779).