In 1825 she became the first HBC vessel to trade with the Pacific Northwest, competing directly with the Boston fur traders.

She made three voyages to Fort George on the Columbia River, and was lost on 10 March 1829 on her fourth as she was arriving there.

[2] She carried as a passenger the noted botanist Davi Douglas, who was on a plant-gathering expedition for the Royal Horticultural Society.

[2] On 25 September 1826 William and Ann sailed for the Columbia River in company with another HBC vessel, the schooner Cadboro.

[2] On 16 September 1828 William and Ann, John Swan, master, sailed from Plymouth, bound for Fort Vancouver.

[3][4] The Clatsop were later exonerated, but only after a punitive expedition from Fort Vancouver had burnt one of their villages and killed a number of its inhabitants.