The school offers a comprehensive program with multi-level instruction in many academic areas.

Boys' sports include football, basketball, baseball, bowling, cross country, golf, ice hockey, lacrosse, gymnastics, wrestling, soccer, swimming and diving, volleyball, and track and field.

Girls' sports include cross country, basketball, bowling, golf, field hockey, gymnastics, soccer, softball, volleyball, lacrosse, track and field, soccer, swimming, and diving.

In 2013 the Williamsville North football team made it to the Class A Championship for the first time in school history, but lost.

The Williamsville North ice hockey program has won multiple Division 1 New York state titles.