[1] By his first wife Elizabeth Knollys, daughter of the privateer Sir Henry Knollys, he had a daughter Elizabeth, who married the noted antiquarian Sir Simonds d'Ewes.
The Willoughby Baronetcy, of Wollaton in the County of Nottingham, was created in the Baronetage of England on 7 April 1677.
The Willoughby Baronetcy, of Baldon House in the County of Oxford, was created in the Baronetage of Great Britain on 8 December 1794 for Christopher Willoughby.
The third Baronet sat as Member of Parliament for Yarmouth, Newcastle-under-Lyme and Evesham.
The fourth Baronet represented Leominster in the House of Commons.