[10] Admired for his use of new and innovative materials and his forceful architectural statements, Furness chose to have the trains move right through the second floor of the station, with room for a ticketing and retail concourse at ground level underneath the tracks.

The north end of the station has a four-faced rectangular clock tower that rises an extra story above the main roof.

[8][14] On January 20, 2017, within an hour after completing his tenure as vice president, Biden boarded an Amtrak Acela train in Washington, D.C. bound for his namesake station.

Amtrak Thruway service is provided through the station to Dover, Delaware and Salisbury, Maryland via Greyhound Lines.

It is also served by SEPTA Regional Rail's Wilmington/Newark Line with service to Center City Philadelphia and Newark, Delaware.

Greyhound Lines provides direct, one-seat ride service from the bus terminal to various cities including Baltimore, New York City, Norfolk, Philadelphia, Richmond, and Washington, D.C.[18] DART First State bus routes serving Wilmington station include 2, 5, 6, 10, 11, 13, 14, 18, 20, 28, 33, 35, 37, 40, 52, 301, and 305 (seasonally).

Senator Tom Carper, Wilmington Mayor Mike Purzycki, DelDOT Secretary Jennifer Cohan, and DART First State CEO John Sisson in attendance.

The Wilmington Transit Center serves most DART First State bus routes in Wilmington and includes a covered waiting area with seats, real-time bus displays, a ticket sales office, restrooms, vending machines, bicycle racks, and parking.