[1][2] Wilson's Heart is a virtual reality horror adventure played in the first person perspective and in black and white.

He then encounters a group of survivors: Bela Blasco (Alfred Molina), who claims to be a surgeon in the hospital; Elsa Wolcott (Rosario Dawson), a young woman; Kurt Mosby (Michael B. Jordan), who claims to be a visitor in the hospital; and Lucy Holmes, a prepubescent 9 year old girl.

Bela then notices that Wilson has in his chest, in place of his heart, a strange orb containing moving parts.

When Wilson meets Lucy again, he realizes, to his utter shock, that she is a vampire when she murders and drinks the blood of a hospital orderly.

After stumbling through the hospital and encountering and defeating several creatures like a tentacle monster, the teddy bear, a zombie soldier, a human-fly hybrid, Mutant Fishmen and animated wooden dummies, Wilson is knocked out by the humanoid monster which took away Elsa earlier and wakes up shackled in a large laboratory.

While she is preparing the procedure, Kurt sneaks into the laboratory and tries to free Wilson, but he is prevented from doing so by the full moon, which appears in the window and transforms him into his werewolf form, and he is attacked by Andy.

In the chaos, Wilson manages to give Andy an electric shock which overloads his brain, leading him to throw Elsa out of the window.

The game ends with Wilson breathing in the narcotic for the heart transplant operation and falling unconscious.

Reviewers commended the black-and-white graphics,[6][3] campy horror atmosphere[4] and voice acting,[7] but they criticized the trivial puzzles,[2] limited and arbitrary interactivity,[8] illogical story[2] and repetitive and frustrating fight sequences.