Wole is the son of Professor Alfred Sobojeyo [4] of the Ohio State University [5] and Anthonia Soboyejo.

[10] Between 2012 and 2014, Soboyejo served as president and provost of the African University of Science and Technology (AUST) in Abuja, Nigeria.

[11] In September 2016, Wole joined the faculty and administration at Worcester Polytechnic Institute (WPI) where he served as the Bernard M. Gordon Dean of Engineering and Professor of Engineering Leadership,[10] prior to being named Senior Vice President and Provost.

His current projects include the use of nanomaterials for targeting and treating cancer; a shear assay technique that may be able to measure the mechanical properties of organelles in the cell; the development of low cost solar cells/light emitting devices; and sustainable approaches to providing clean water, affordable housing and education to people in the developing world.

[12] In 2021, he was elected a member of the National Academy of Engineering for contributions to understanding dynamic behavior of materials and for leadership in STEM outreach in Africa.