[1] Located in northwest Wisconsin, the district comprises all of Buffalo, Pepin, Pierce, and St. Croix counties, along with most of Trempealeau and parts of western Dunn County.

It also contains landmarks such as Kinnickinnic State Park, Perrot State Park, Trempealeau National Wildlife Refuge, and part of the Saint Croix National Scenic Riverway.

[2] Northwestern portions of the 10th Senate District are located with the Minneapolis-Saint Paul Metropolitan Area.

[5] Note: the boundaries of districts have changed repeatedly over history.

Previous politicians of a specific numbered district have represented a completely different geographic area, due to redistricting.