[1] Located in southeast Wisconsin, the district is entirely contained within central Milwaukee County.

It contains landmarks such as the Marquette University campus, Fiserv Forum (home of the Milwaukee Bucks), the Milwaukee Public Museum, historic Holy Cross Cemetery, and the Miller Brewing Company.

The 6th district was defined as Grant County, in the southwest corner of the state.

After the fifth session (1852) of the state legislature, the Senate was expanded to 25 members and a reapportionment occurred.

Through the subsequent 160 years of redistricting, the 6th district has remained in this location, though the boundaries have shifted.