It runs in north–south in south central Wisconsin from Madison to Baraboo, following the Chicago and North Western Railway.

It runs northward as a divided highway through the northeast side of Madison and around the northern shore of Lake Mendota before crossing the Yahara River and exiting the city into the town of Westport.

WIS 113 continues north-northwesterly through the town of Lodi along the shore of Lake Wisconsin.

WIS 113 uses the ferry to cross Lake Wisconsin and into Sauk County.

North of Cuba Valley Road, the WIS 113 designation was moved to McChesney Road for two miles (3.2 km) north to CTH-V and westerly on CTH-V for one mile (1.6 km) until it rejoined the old alignment.