It runs north–south in central Wisconsin from Fall River to Cambria.

At this point, the route ends there and continues as County Trunk Highways M (CTH-M).

[2] The first iteration of WIS 146 was established in 1923 to connect Bellevue southeast of Green Bay to Kewaunee at the lake.

[3][6] It was renumbered to WIS 146 in 1926 to avoid duplicating a newly-established U.S. Highway with the same number in Wisconsin.

[5] The entire highway is in Columbia County.