[5][6][7] After US 41 bypassed downtown Appleton, Neenah, and Menasha in 1938, a part of WIS 150 on Lake Street was rerouted westward onto US 41 (Green Bay Road).

[8][9] In 1959, US 41 between Neenah and US 10 (now WIS 96) was moved onto a new limited-access highway.

[10][11] In 1975, US 41 from WIS 110 in Oshkosh to US 10 in Appleton was upgraded to interstate standard.

However, in that same year, WIS 150 no longer served downtown Neenah.

[16][17] In 2003, WIS 150 was decommissioned after the US 10 expressway was completed and became part of CTH-II's western extension.