State Trunk Highway 160 (often called Highway 160, STH-160 or WIS 160) is a state highway in the US state of Wisconsin.

It runs in east–west in east-central Wisconsin from Angelica to Pulaski.

Starting at WIS 29/WIS 55 junction in Angelica, WIS 160 travels eastward.

Initially, in 1923, WIS 160 was established to bypass WIS 16 from Mill Center to Angelica through downtown Pulaski.

[6][7] In 1996, the route was slightly truncated in favor of the WIS 29 expressway.