It runs east–west and north–south in east central Wisconsin from near Neenah around Appleton to near Little Chute through Winnebago, Outagamie and Calumet counties.

The Roland Kampo Memorial Bridge spans Little Lake Butte des Morts near the highway's southwest terminus.

[1] The bridge, designated County Trunk Highway Q (CTH-Q) for its first years, extended from US 41 to CTH-P (Racine Road), approximately 1.3 miles (2.1 km).

[1] Between 2012 and 2019, the Wisconsin Department of Transportation (WisDOT) worked to a widen WIS 441 from east of I-41 to west of Calumet Street from four to six lanes along with changes to interchanges along the section.

Property was also acquired to allow the smoothing of two sharp curves from the Kampo Bridge to north of Midway Road.