After crossing the bridge, it soon turns east via WIS 35/Great River Road.

In Centerville, WIS 35, as well as the Great River Road, turn southward; leaves the concurrency.

However, as they travel eastward, WIS 54 turns northeast, leaving the concurrency.

After leaving Butman Corners, it closely parallels the Black River just south of the route.

In Black River Falls, it briefly runs concurrently with US 12 and WIS 27 on the bridge.

After crossing the bridge, WIS 54 becomes a four-lane divided highway.

After leaving Vaudreuil out northeast, WIS 54 then downgrades into a two-lane undivided highway.

This concurrency with WIS 13 runs from the west end of the Wisconsin River bridge to 8th Street.

At Robinson Park, WIS 54 curves east, and - passing 64th Street - becomes a four-lane, divided highway with a 65-mph (104 km/h) speed limit to just outside Plover.

Continuing northeast, they then run concurrently with WIS 110 for 2.3 miles (3.7 km).

Near the Newton Blackmour State Trail in New London, US 45 meets WIS 54 at a parclo.

After entering Green Bay, WIS 54 becomes a four-lane divided highway.

It continues to travel eastward through the Door Peninsula until reaching WIS 42 in downtown Algoma.

[7] The Wisconsin Department of Transportation (WisDOT) plans to add roundabouts at two intersections along WIS 54 in Seymour.

Construction will begin in early 2024 and is expected to end later in the year.