Created by Chuck Jones during the golden age of American animation, the character was originally voiced by Bea Benaderet in 1954's Bewitched Bunny.

Benaderet would later be replaced by June Foray, who voiced the character almost exclusively beginning with 1956's Broom-Stick Bunny and concluding with 2002's Twick or Tweety.

After Foray's departure from the role, the character was voiced by Roz Ryan from 2011 to 2013 for The Looney Tunes Show (as Witch Lezah) and by Candi Milo from 2017 onward.

Different characters of the same name appeared in several studios' short films throughout the golden age of American animation: the first was in the Disney cartoon Trick or Treat (1952), voiced by June Foray.

Bugs Bunny witnesses her coax the children inside and saves the youths from Witch Hazel's clutches because the Masked Avenger is not around.

Jealous that this newcomer is uglier than herself, Hazel attempts to trick the "witch" into drinking a "Pretty Potion" disguised as tea.

Bugs calls Air Raid headquarters to alert them about a "Flying Socceress chased by a Genie with light brown hair."

Once production shifted to DePatie–Freleng Enterprises, Witch Hazel appeared in the cartoon A-Haunting We Will Go (1966), which also starred Daffy Duck and Speedy Gonzales.

June Foray recorded new and redubbed dialogue for Witch Hazel in the special, including in newly animated content to link the classic clips together into one narrative.

She was also featured as the lead antagonist in DC Comics' three-issue Bugs Bunny miniseries from 1990 (though at the ending of the storyline, her appearance there is actually revealed to be a disguised Wile E. Coyote).

Witch Hazel has a cameo in the video game adaptation of Looney Tunes: Back in Action as a painting parodying the Mona Lisa in the Louvre Museum.

Witch Hazel also starred in the New Looney Tunes segments "Finders Keepers, Losers Sweepers", "Hiccups and Downs" and "It's Snout or Never".

Witch Hazel made her first appearance in the Looney Tunes Cartoons short "Hex Appeal", which is part of a Halloween special titled Bugs Bunny's Howl-O-Skreem Spooktacula.

[3] Lezah ("Hazel" spelled backwards) is voiced by Roz Ryan, who gives the character a pronounced African American patois.

In "Best Friends Redux", Witch Lezah has a time portal in her home, which Daffy uses to jealously ensure that Bugs Bunny and Rodney Rabbit never meet.