[2] The cast includes Veena Sood, Donna Benedicto, Arghavan Jenati, Laara Sadiq, Ryan Beil, Kerën Burkett, Enid-Raye Adams, Miho Suzuki, Ken Godmere, Linda Pollard, Jennifer Copping, Michael Daingerfield, Lynda Boyd, Calix Fraser and William Vaughan.

Anabel (Anna Maguire), an artist who is one of the few remaining people who still experience a world of individuality and emotion, falls in love with George (Hamza Haq), a man who is part of the dominant paradigm and who rejects her because LifeZap has not selected her for him.

Heartbroken, Anabel removes her heart so that she can finally blend into the norm, and sends it to George, who places it in his own chest and begins to experience genuine emotion and individuality for the first time in his life.

"[3] She further stated that "With Love and a Major Organ has moments of fantastical surrealism, including a whimsical dance sequence that is reminiscent of a bygone era of film, as well as the premise that hearts are inanimate objects that can be removed and replaced.

Albright grounds each of these elements with a down-to-earth production quality that grants audiences the ability to suspend disbelief easily, which is further aided by a humorous script by Julia Lederer.