"Without You I'm Nothing" is a 1999 single by British alternative rock band Placebo.

The title track of their second album, the single version featured additional vocals by David Bowie.

This song was also featured in an episode of Queer as Folk and the mexican movie Amor, Dolor y Viceversa (Love, Pain and, Vice versa).

The song returned to live shows during the band's UK tour in April 2012, but was not performed during the Summer leg of the tour.

It was also featured in the 2016 arena tour with accompanying visuals of Bowie working with the band to produce the track.