The station is located at the Wittenbergplatz square in Berlin's City West area, in the northwestern corner of the Schöneberg neighbourhood.

Initially a common underground station with two tracks and two side platforms, it was completely refurbished as an interchange from 1910 onwards.

The remarkable entrance hall in the centre of Wittenbergplatz, designed in an Art Nouveau style by Alfred Grenander, was finished in 1913; spanning over all three platforms, it reflected the prestigious building of the large KaDeWe department store across the street.

The station building was badly damaged during the bombing of Berlin in World War II and reconstructed afterwards.

[3] Platform 1 features a sign donated by the London Transport Executive in 1952 to commemorate the 50th anniversary of the U-Bahn.