Later, he resigned from his job as school principal and moved to Semarang to work at the railway company, Nederlandsch-Indische Spoorweg Maatschappij.

In 1925, Wiwoho and his colleagues founded a Muslim youth organization named Jong Islamieten Bond (JIB) and he was appointed as the vice chairman.

[2] As a member of Volksraad, Wiwoho proposed a motion that required a five-year transitional period before Indonesia became an independent country due to the political situation in Asia, and together with Mohammad Husni Thamrin and Soetardjo Kartohadikusumo, he filed a motion to the Dutch colonial government to replace the name of Dutch East India into Indonesia in August 1939.

On 29 July 1931, he protested Hoa Kiao magazine for writing an article that mocked Prophet Muhammad.

One month later, on 7 August 1931, Wiwoho complained about the article made by Jan ten Berge [nl] that offended Muslims.

Afterward, he was designated as Head of the Secretariat of Staff of Region V Military Government in Java.

On 21 January 1950, Wiwoho was appointed as the Minister of Information Republic of Indonesia in the Halim Cabinet, replacing Raden Sjamsoeddin.