He is a Harrison Distinguished Professor of Molecular Physiology and Biological Physics at the University of Virginia.

After moving to the United States in 1985 and working with Michael Rossmann at Purdue University, he gradually switched into the field of macromolecular crystallography.

[8] While at Purdue, Minor started a collaboration with Zbyszek Otwinowski [pl], with whom they developed software for processing X-ray diffraction data (Denzo, Scalepack, XDisplayF).

[12] The lab was also a part of the Center for Structural Genomics of Infectious Diseases (CSGID)[13] and the Enzyme Function Initiative.

[8] The Minor lab has developed many other software tools for structural biology, including proteindiffraction.org (a public repository of diffraction images),[14] CMM (a server for validation of metal-binding sites in macromolecular structures),[15] CheckMyBlob (a machine learning system that automatically detects and validates ligands in X-ray electron density map),[16] and LabDB (a laboratory information management system for structural biology).